Keloid Disorder (KD) is an inherited wound healing ailment, frequently seen among Africans /African Americans and Asians. KD has a fascinating and very diverse presentation. In some cases, the disease is limited to one or few small lesions of the skin; either round or linear; in other cases, keloids can appear as large nodules, the conglomerate of nodules, or appear as very large patches or tumors. Such a diverse presentation is most likely tied to a complex and poorly understood genetics. Keloids develop in genetically predisposed individuals as a consequence of injury to the skin that acts as a triggering factor for the formation of the keloid lesions. The triggering factors range from minor inflammatory skin reactions seen with acne, chicken pox, vaccination; or from body piercing, surgical wounds, burns, etc. Although reported in individuals from almost all ethnic backgrounds, the disease is more common among two distinct and genetically distant populations; Africans / African Americans and Asians. Much more research needs to be done to determine the genetic roots of keloid disorder. Lack of progress in keloid disorder is in part due to lack of a lobbying group for this condition. Although quite common, keloid has not captured the interest of research community. This needs to change.