Abstract:Familial keloids associated with familial Noonan syndrome

ABSTRACT

Background: Spontaneous keloids are benign fibroproliferative tumors that extend beyond the original wound and result absent a significant history of trauma. Spontaneous keloids have been reported mainly in association with certain syndromes.

Case presentation: A 26-year-old female presented to the dermatology department with skin lesions on her body that had been present for 22 years. These lesions first appeared on the right foot and then spread to multiple sites. They were itchy, some were painful, and they never went into involution or decreased in size.

Discussion: Keloids are benign fibroproliferative tumors that extend beyond the original wound. Spontaneous keloids result absent a significant history of trauma and they are diagnosed mainly from history taking. It is generally believed that keloids are triggered by microtrauma in genetically susceptible patients.

Conclusions: While no optimum treatment modality has been demonstrated for spontaneous and recurrent keloids in adults, surgical resection and adjuvant radiation therapy may provide an effective option for patients with large symptomatic keloids, with notable clinical success rates.


Abstract     Full-Text     Download