Usage of cryotherapy in treatment of keloids dates back to 1950 . There are numerous references about efficacy of cryotherapy in treatment of keloids [2,3]. Focus of this Guideline, however, is not to review this literature. The aim of this document is to discuss the method for proper application of this treatment modality as well as review of the clinical outcomes. Terms cryotherapy in this document and in the rest of the KRF Guidelines refers to contact cryotherapy. KRF does not endorse other methods of applying cryotherapy such as spray gun, intra-lesional.